Intracellular Traffic
http://www.nmsu.edu/~molbio/mcb520/lecture7.html
http://www.nmsu.edu/~molbio/mcb520/lecture8.html
Detailed description of devices cells use to separate and store substances (lecture7), and how a cell moves these substances (lecture8). These pages are very detailed and likely accurate, since they come from an academic institution. General: 3
http://cellbio.utmb.edu/cellbio/recend.htm
Since cells often transport substances contained/protected by lipid layers, exo- and endocytosis are important mechanisms in intracellular transport. This site provides overviews, self-tests, and many images and links. Specifically, this page focuses on ligand-receptor mechanisms for triggering endocytosis. Specific: 4
http://www.ktl.fi/bios/know/traffic.html
This site was produced by an individual working with intracellular transport mechanisms. This page is an introduction to the types of problems a cell faces when these transport pathways are not functioning properly. General:4
http://shubashi.physiology.rwth-aachen.de/bs/erys/shapes/
Here they present the results of vesicle shape calculations sorted by constraints on volume (v) and area difference (h). A well-made Java program. Very useful if you ever need to determine the shape a vesicle will take based on these parameters. Specific: 4
http://www.ultranet.com/%7ejkimball/BiologyPages/P/ProteinKinesis.html#rer
A very comprehensive site discussing protein kinesis. Good illustrations, and several links to more related information. The author gives good credentials, and seems to be well organized. Specific (but linked to a General index): 5
http://vl.bwh.harvard.edu/labs.shtml#membranes
This site provides a list of lab exercises that pertain to investigations into Membranes, Organelles and Vesicle Trafficking. Specific: 2
http://dir.nichd.nih.gov/cbmb/pb1labob.html
Web summary of Nature, Volume 389, Pages 81-85 1997 that contains many quality animations (note: the movie player plug-in must be installed). Discusses experiments regarding the transport pathways of the Golgi apparatus. Specific: 3
Cell Scaffolding
http://expmed.bwh.harvard.edu/
This site summarizes research on actin at the Brigham and Women's Hospital. It has lots of information and some interesting movies about cell motility and its relation to the cytoskeleton. Rank: 4.
http://gened.emc.maricopa.edu/bio/bio181/BIOBK/BioBookCELL2.html
This is a portion of an online biology textbook. It contains very good cartoon illustrations of cellular scaffolding components and a description of their use in inter- and intracellular motility. Rank: 5.
http://dir.nichd.nih.gov/CBMB/uobf3a.mov
This is a movie of vesicular traffic into the Golgi, visualized with Green Fluorescent Protein. Not much information about cellular ,scaffolding, but a nice way to visualize the intracellular motion made
possible by the scaffold. Rank: 2.
http://www.cbc.umn.edu/~mwd/cell_www/chapter2/skeleton.html
This site is currently incomplete/under construction, but it has some interesting facts about centrioles and actin. Further entries regarding other components of the cytoskeleton are presumably forthcoming. No images. Rank: 2.
http://web-mcb.agr.ehime-u.ac.jp/bunnshi/sec7.htm
This site provides an excellent summary of the unique features of cellular scaffolding in plant cells. No images. Rank: 4
Molecular Motors
http://www.sci.sdsu.edu/movies/actin_myosin_gif.html
Actin myosin crossbridge 3-D animation. The animation shows the need for one ATP to make the myosin complex "walk".
http://199.17.138.73/berg/ANIMTNS/kinesin.htm
This site has a diagram showing how kinesin pulls "things" down the microtubule away from the cell in the negative to positive direction. Also, this site contains a link to more information on dynein.
http://mc11.mcri.ac.uk/hypertour.html
A very good site decribing the role of molecular motors. The site contains links to diagrams which further explain how molecular motors "walk" along the microtubules in order to pull chromosomes into position.
http://www.ascb.org/ascb/mbc/brochuretxt.htm
This site tells why molecular motors are so important to study. It also gives a detailed description of myosin versus kinesin, including various universities studying this topic.
http://pmi.princeton.edu/faculty/SMB.html
Dr. Steven M. Block discusses his research interests in molecular motors and
why he feels it is important to study them. It also gives 3 reasons why a
motor mechanism is difficult to construct.
Intercellular signaling (Cell Signaling)
http://www.bio.nd.edu/biology/faculty/goetz.html
A very specific website that pertains to intercellular signaling. This website was developed by one author, Dr. Frederick W. Goetz, a professor at the University of Wyoming. Dr. Goetz is studying the mechanisms and hormonal regulation of ovulation in zebrafish. More specifically he is determining the genes responsible for mutations involved in oogenisis and spermatogenisis. There are images present. (5)
http://www.ummed.edu/pub/l/ldasso/
A website created by Dr. Leonardo Dasso of the University of Massachusetts Medical School. Included in this website is a specific, but brief, overview of Dr. Dasso韘 research on the function of Ca2+ and cAMP in intercellular signaling. More specifically, Dr. Dasso researched the role of Ca2+ and cAMP in increasing the beat frequency of cilia in epithelial cells. This website also has links to selected publications and other pertinent articles. (4)
http://cpmcnet.columbia.edu/dept/gsas/anatomy/cndb_it.html
This website is a link to Dr. Richard H. Kessin of Columbia University. It can be found by double clicking Dr. Kessin韘 name in "Intercellular signaling." This is a specific website that can be a link to other articles written by this professor and other professors that deal with intercellular signaling. Dr. Kessin韘 website focuses on the evolution and mutagenisis of Dictyostelium discoidenum. Minimal pictures are present. (3)
Intracellular Signaling (Receptors, 2nd messengers)
http://www.geocities.com/CollegePark/Lab/1580/cdc42.html
This site gives a very thorough and easy to understand view of Cdc42 (a G-protein) and its uses inside the cell. This site gave a simplified and clear presentation of the processes involving Cdc42. There are links along the way through the page to other pages that go into detail about G-proteins in general, cell cycle control, and other topics important for the understanding of the functions of Cdc42. This page also has several diagrams along with text to further the explanations of the topic, and at the bottom provides links to other material concerning cellular biology.
http://flybase.bio.indiana.edu:7088/.data/allied-data/interactive-fly/aignfam/camplern.htm
This page contains links to webpages that discuss G-proteins, cAMP, and other cell related chemical reactions and proteins. This page is good as a resource for intracellular communication "techniques" used by cells and gives fairly lengthy overviews of what these proteins do, although most of this site is directed at the cAMP second messenger system process. Even though it lacks any diagrams, it is still a good site for written information.
www.bio.davidson.edu/biology/courses/immunology/flash/ip3.html
This site is operated by a Davidson Professor (Dr. Campbell) and portrays a step by step animated visual of an IP3 signal transduction pathway. This is the only visual that this site shows, however it is very helpful in understanding a basic intracellular communication technique in a very comprehensible manner.
www.ariad.com/st_over.html
Ariad, a pharmacological research company that explores "intracellular protein interactions that make up signal transduction pathways," has established this site. The company韘 focus is the creation of small molecule drugs that inhibit signal transduction pathways. We chose this as one of our top sites for its diagrams as well as its links to more specific information about the cell proteins it researches.
http://www.clarke-inst.on.ca/research/cellular_communication.html
This site reveals the mission of Dr. Jerry Warsh as he attempts to elucidate the significance of intracellular signaling disturbances in manic depressive illness (bipolar disorders). This site describes the importance of calcium levels as cell signaling devices and G-proteins as surface membrane protectors. Though lacking diagrams and specifics of their research it presents an interesting explanation into symptomatic effects of errors in intracellular signaling processes.
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